2007年12月29日星期六
Is Privacy Where It's At?
2007年12月27日星期四
Business Intelligence's Feeding Frenzy
2007年12月21日星期五
More Legal Woes for Vonage
Liberty Alliance Unveils Improved SAML Certification
Pressure Mounts on Google/DoubleClick
Supply TOCOS potentiometer RV24YN B502
http://miede.109876543210.cn/n/Supply-TOCOS-potentiometer-RV24YN-B502-TaleVF1q/
2007年12月20日星期四
Microsoft, Viacom in $500 Million Ad Deal
Oracle, Accenture Deliver the Goods
2007年12月18日星期二
Why Seniors Say "When" Too Soon
By Benjamin Lester
ScienceNOW Daily News
17 December 2007
Thirsty old folks drink less water than parched whippersnappers because their brains are more easily satisfied, according to a new study. The findings suggest that the brain's satiation mechanisms malfunction as we age and might help explain why seniors are at greater risk for dehydration.
Feelings of thirst stem from two main changes in the blood: a higher concentration of salts and a lower concentration of water. Ordinarily, the feeling of thirst prompts us to drink enough water to restore a balance. However, researchers have known for several years that older people tend to drink less, and the reason has remained unclear.
Curious about whether the fault lay in the brain, a team led by neuroscientists from the University of Melbourne in Australia induced thirst in 10 men in their 20s and in 12 men in their 60s or 70s by injecting them with a salty solution. The scientists then spied on the subjects' brains using positron emission tomography, which measures changes in blood flow.
The salt cocktail prompted similar feelings of thirstiness in the young and old subjects, as well as similar changes in cerebral blood flow. However, the older men drank nearly 50% less water than did the younger men. A possible explanation showed up in the brain scans. In the older subjects, blood flow to a brain region called the anterior midcingulate cortex--a regulatory area that was previously linked to feelings of thirst--decreased much more per sip than it did in the younger group. According to the team, the observed difference might mean that in older people, the brain misinterprets signals from the digestive tract about how much water has been drunk, leading to a false sense of satiation, the team reports online this week in the Proceedings of the National Academy of Sciences.
Nina Stachenfeld, a physiologist at Yale University, says previous studies had hinted that the phenomenon might have a cerebral explanation and that the scanning information "adds significantly to the field." However, she notes that the team made some potential errors, such as allowing the subjects to drink for only 8 minutes. The 8-minute window was sufficient to study brain function, she says, but it may not tell the full story. "In our studies," she says, "we found in this early period, the older subjects drank less than younger subjects, but they quickly caught up."
Answers Elusive in Kessler Firing
By Greg Miller
ScienceNOW Daily News
17 December 2007
Key questions remain unresolved in the firing of dean David Kessler by the University of California, San Francisco (UCSF) School of Medicine last week. Kessler and the university had been at odds over "financial irregularities" Kessler says he discovered shortly after taking the post in 2003.
In a 17 December statement, the university said that Chancellor J. Michael Bishop asked Kessler in June to hand in his resignation by the end of the year. With no resignation forthcoming, Bishop formally dismissed him on 13 December. "The reasons for Dr. Kessler's dismissal ... cannot be discussed, as they represent personnel matters that are held confidential in compliance with University policy and state law," the statement read. As ScienceNOW went to press, the university had not made Bishop or other university leaders available for media interviews.
Kessler and UCSF had a long-running disagreement involving the amount of discretionary money available to him as dean for research and educational initiatives, faculty recruitment, renovations, and other uses. Kessler says there turned out to be far less money flowing into the dean's office than he was led to believe when UCSF recruited him away from his previous post as dean of Yale School of Medicine. At that time, Kessler says, UCSF gave him documents showing a gross income of $46.4 million for the most recent fiscal year (2001-2002), resulting in a $9.9 million surplus for the dean's coffers after expenditures. Kessler says this level of funding--which the university projected would continue in future years--was an important factor in his decision to move to UCSF. "With an income of $46 million, you could do the things you needed to do."
But when Kessler asked Jed Shivers, then vice dean for administration, finance, and clinical programs, to conduct a review in late 2004, the numbers didn't match--even for fiscal years that had already come to a close. For 2001-2002, for example, Shivers's analysis showed income of just $28.3 million and a deficit of $7.8 million, which would deplete the dean's account within a few years. Kessler says he was baffled. "For the same closed year, how can you have two different revenue numbers?"
The answer to that question is devilishly hard to pin down. Shivers, now associate dean of finance and administration at Albert Einstein College of Medicine of Yeshiva University in New York City, says his financial team at UCSF was never able to square the numbers Kessler was originally given: "To this day, we can't figure out how that data he received could be reconciled to the books of the university." Yet according to statements issued by UCSF, the university auditor completed a report in June that found no financial irregularities; neither did two additional reviews, one by a group of senior financial officers and another by an outside accounting firm.
In 2005, just as Kessler was beginning to delve into the dean's office finances, an anonymous letter surfaced, accusing him of lavish and irresponsible spending. (Auditors later concluded that the allegations were unfounded.) In its 17 December statement, UCSF "categorically denies" that Kessler "was dismissed in retaliation for his allegations about financial irregularities in the UCSF School of Medicine."
Prior to his post at Yale, Kessler was commissioner of the Food and Drug Administration from 1990 to 1997, where he spearheaded a major investigation into the tobacco industry and instituted limits on tobacco advertising directed at children. He plans to retain his post as professor of pediatrics/epidemiology and biostatistics at UCSF. The university has named Samuel Hawgood, chair of the department of pediatrics and physician in chief of UCSF Children's Hospital, as interim dean of the medical school.
2007年12月17日星期一
E-Commerce Sales, Outlook Less Than Fantastic
Microsoft Dynamics CRM 4.0 Ready for Download
Topping Hollywood: Software's Frenzied Year
The SaaS model gets some respect Rather than locking themselves into never-ending license service contracts -- to say nothing of the months or years it takes to complete an on-premise software implementation -- companies of all sizes are increasingly turning to Software-as-a-Service (SaaS) (define) for their daily business applications. This has been good news for providers like Salesforce.com and NetSuite. Salesforce.com during the year extended its lead in the sector. The company reported strong earnings, customer wins (including many wins against on-premise competitors) and the launch of its platform-as-a-service offering, Force.com, for developers to build and deliver any application they want, on demand. Cisco Systems' $3.2 billion purchase of WebEx in March now positions the network-equipment maker as serious threat to top-tier enterprise software vendors servicing corporate customers that are increasingly enamored with the SaaS model for unified communications and collaboration. Meanwhile, Microsoft is expected to launch its CRM Live on-demand product early next year. Oracle in November announced plans to beef up its Siebel CRM On Demand service with a slew of social networking features. But the strongest vote of confidence for the SaaS model may have come in fall, when SAP -- the world's largest business application vendor -- jumped on the bandwagon with its first on-demand service, Business ByDesign. In announcing what amounts to a sea change in the German company's strategic direction, CEO Henning Kagermann stepped up the rhetoric when he called Business ByDesign "the most important announcement I've made in my career." That a company of SAP's size and stature would spend more than $500 million to launch what can only be viewed as a direct challenge to Salesforce.com makes it perhaps the most resounding endorsement of the SaaS model. Believe it or not, Salesforce.com, which eclipsed the 1 million-subscriber threshold in 2007, is pleased by the turn of events. "I feel like sending Henning Kagermann a fruit basket today," Bruce Francis, Salesforce.com's vice president of corporate strategy, said in an interview with InternetNews.com in September. "This is a fantastic thing. What SAP is doing is confusing their customer base and opening minds and markets for the SaaS model." And then there's NetSuite. On Dec. 6, the company finally formalized its initial public offering, filing to sell 6.2 million shares for between $13 and $16 a share. NetSuite, which is majority-owned by Oracle CEO Larry Ellison, hopes to raise almost $100 million to pay down some debt and build a second datacenter. Despite being an early mover, the company has yet to turn a profit, however. And SaaS isn't a sure-fire win for SAP, either. The model may have received the nod from the software giant, but it still represents a gamble. Business ByDesign "is a big bet for SAP," Gartner analyst Dan Sholler said in an interview with InternetNews.com in August. "This has to succeed or they will have a whole host of business challenges ahead of them. No one has ever proven they can sell this type of business technology this way. SAP is betting the profitability of the company that it will be able to do it." Continued on Page 2: The SAP-Oracle war rages on.
2007年12月15日星期六
Supply the lifting hook quinonoid formula throws pill fettle machine to throw pill machine sand - bl
http://zt.zhikediguo.com/m/Supply-the-lifting-hook-quinonoid-formula-throws-pill-fettle-machine-to-throw-pill-machine-sand--blaster-Tu2-Zhuang-Xian4-FJUTMMDs/
2007年12月13日星期四
Remote Lake May Be Treasure Trove of Climate Data
By Phil Berardelli
ScienceNOW Daily News
13 December 2007
Canada and the northern United States are dotted with tens of thousands of lakes, most of them formed by meltwater at the end of the last ice age about 12,000 years ago. Sediments at the bottom of those lakes hold chemical and biological evidence of how the planet's climate has varied for even longer periods, over many ice ages and interglacial cycles, and how those variations have affected the local ecosystems. But almost all of these sediments have been bulldozed repeatedly by glaciers as the giant rivers of ice have advanced and retreated over the last 2 million years, scrambling the geological record.
Pingualuit Crater in northern Quebec seems to have escaped this fate. Its 3.7-kilometer-wide, nearly circular lake not only is deep enough--nearly 270 meters--to have avoided the glacial pummeling but also has remained sequestered from any other body of water during its entire history. So the sediment that has collected on the lake's bottom has preserved a pristine record of the climate and biological activity in the lake for more than a million years--much longer than any similar climate data source currently available. Until recently, however, the technology necessary to retrieve samples from the bottom, without disturbing the samples or contaminating the lake's ultraclear water, did not exist.
So, paleolimnologist Sonja Hausmann of the University of Arkansas, Fayetteville, and colleagues employed a new type of coring rig devised specifically for obtaining delicate samples. Last May, after trekking across the then-frozen lake on foot without the aid of potentially polluting snowmobiles or sled dogs, the team deployed the bottom-dwelling rig, which is suspended from a Kevlar cable, and spent 2 weeks carefully extracting cores from the top 10 meters of Pingualuit's estimated 150 meters of sediment. Those samples are beginning to provide a treasure trove of data going back at least 250,000 years.
"We think the samples span at least two [interglacial] cycles," Hausmann says. They include diatoms--microscopic algae whose silicate shells can provide exquisite historical portraits of the lake's water quality and climatic conditions--as well as trace metals and pollen that have fallen from the atmosphere. Other records can be compiled from sources such as the ice cores in Greenland and the sea beds, she says, but the Pingualuit cores are the only ones available from the North American land that contain the skeletal remains of climate-sensitive algae.
"Collecting this core was no small endeavor," says paleolimnologist John Smol of Queen's University in Kingston, Canada. "Many of us had previously assumed that the last Ice Age had obliterated older sediment records," he says, but Pingualuit's cores show that "there is a remarkable history book still present."
2007年12月12日星期三
HP Snaps Up Another Print 2.0 Play
Alcatel-Lucent Shift: Web Services Security
2007年12月10日星期一
Ten thousand on canal the plant produce quickly the shut type noise elimination nonreturn valve
http://zt.zhikediguo.com/n/Ten_thousand_on_canal_the_plant_produce_quickly_the_shut_type_noise_elimination_nonreturn_valve-9qkI2BWp/
Google, Ask.com Weigh In On The Year In Search
- 1. iphone
- 2. Webkinz
- 3. tmz
- 4. Transformers
- 5. YouTube
- 6. Club Penguin
- 7. MySpace
- 8. Heroes
- 9. Facebook
- 10. Anna Nicole Smith
- 1. MySpace
- 2. Dictionary
- 3. Google
- 4. Themes
- 5. Area Codes
- 6. Cars
- 7. Weather
- 8. Games
- 9. Song Lyrics
- 10. Movies
2007年12月6日星期四
Nielsen Unveils Online Video Tracking Service
2007年12月5日星期三
Faulty Wiring in the Aging Brain
By Greg Miller
ScienceNOW Daily News
5 December 2007
A team led by Harvard neuroscientists Jessica Andrews-Hanna and Randy Buckner used functional magnetic resonance imaging (fMRI) to monitor brain activity in 38 young adults, mostly 20-somethings, and 55 older adults, age 60 or above. The researchers focused on a "default" network of brain regions that are active when the brain is just idling, not working on any particular task (ScienceNOW, 18 January). The fMRI scans revealed coordinated activity in the default network in younger subjects: For example, two particular brain regions in the network tended to be active at the same time even though one is at the front of the brain and the other is near the back. In the older subjects, however, activity in these areas was poorly coordinated. In nine older adults, the researchers also performed a positron emission tomography (PET) scan that can detect amyloid protein in the brain--a hallmark of Alzheimer's disease. The PET scans were negative, suggesting that an out-of-sync default network is a part of normal aging, not a sign of disease, Buckner says.
Additional experiments using a method called diffusion tensor imaging revealed evidence of deteriorated white matter--the cables of axons connecting one brain region to another--in older adults whose default network activity was poorly coordinated. Although the role of the default network in cognition is poorly understood, coordinated activity made a difference in how people performed on tests of memory and other mental skills. Those with the least coordinated default network activity tended to get the lowest scores, the researchers report in the 6 December issue of Neuron.
"I think it's a great contribution to the field of cognitive aging," says neuroscientist Adam Gazzaley of the University of California, San Francisco. The findings, he notes, add to previous hints that the cognitive declines that happen with age result from changes in the way brain regions interact. Deteriorating white matter may turn out to be the root problem, breaking down communication links between brain regions and impairing their ability to work in a coordinated manner, says Gazzaley.
Red Hat Finally Nears Real-Time Linux Launch
2007年12月4日星期二
Ears Too Big? It's All in Your Head
By Constance Holden
ScienceNOW Daily News
3 December 2007
Psychiatrist James Feusner and colleagues at the University of California, Los Angeles, asked BDD subjects and controls to scrutinize images of faces while their brains were being scanned by functional magnetic resonance imaging. Each face was presented in three versions: One was an unaltered photograph; one included only low-spatial-frequency information, resulting in a blurred image that yielded just a general impression of the face; and the third contained only high-frequency information, which exaggerated the lines of the face (see picture).
Previous research has shown that different neural pathways process high- and low-frequency information. When the image is blurry, the normal brain analyzes the face as a whole, whereas with high-frequency data, it zeroes in on details. The scientists found that the control subjects used a more holistic, right-brain strategy for the unaltered face and the low-frequency one. They only moved to the high-detail strategy for the high-detail face. In the BDD group, however, subjects failed to look at the figure as a whole, instead using left-brain channels that dwell on details for all three faces.
Feusner says the people with BDD don't have defective vision, as shown by the fact that there were no differences between the two groups in the activity of the occipital lobe, the brain's primary visual area. The differences show up in their "extended visual processing network," indicating that perceptions get twisted beneath the level of emotion or conscious thought, says Feusner, whose report appears in the December issue of the Archives of General Psychiatry.
Sanjaya Saxena, a psychiatrist at the University of California, San Diego, says that as a rule, psychiatrists have assumed that the distorted perceptions of people with BDD only related to how they view themselves. This study indicates that these distortions go deeper to include perceptions of others, he says. That helps explain why the disorder seems so "ingrained," Saxena says, and suggests that in addition to measures to reduce anxiety and depression, people with BDD might benefit from behavioral therapy aimed at "retraining" their visual processing. Feusner's team is now enrolling patients for the next stage of the study: seeing how patients react to altered and unaltered pictures of themselves.
Microsoft Issues Domain-Related Security Alert
2007年12月3日星期一
IBM Simplifies Mainframe Management
2007年12月1日星期六
Curt Schilling Pitches Software
Source: 38 Studios "I didn't want to do the restaurant thing or the normal stuff" pro athletes often pursue outside of their sports career, Schilling said this week here at VentureWire's Consumer Technology Innovations conference. In fact, Schilling noted he's already deviated from his original plans for entrepreneurship. "This was supposed be my last season" with the World Series champion Red Sox, he said. "But I'm not intelligent enough to go out on top." Instead, the 41-year-old Schilling signed for another year with the Red Sox while remaining heavily involved with 38 Studios, the company he initially called Green Monster Games. Taking a cue from baseball, Schilling said he's assembled an all-star lineup of developers, designers and marketing pros to build the company. The heavyweight roster, which Schilling describes as giving him an "unfair advantage," includes Todd McFarlane, creator of the Spawn comic book as art director. It also includes fantasy author R.A. Salvatore as creative director and video game veteran Brett Close as CEO. For now, the company is tight-lipped on specific titles or the categories it intends to go after, aside from indicating that it's focused on the Massively Multiplayer Online (MMO) fantasy role-playing genre. "We'll have Web 2.0, episodic, graphical content for wireless and console products that all tie into the online world," CEO Close told InternetNews.com. "No one's put it all together yet." The opportunity to get a piece of the action currently dominated by such MMO heavyweights as Blizzard (with "World of Warcraft," or "WoW") and Sony Online Entertainment (which produces "EverQuest") is huge. Schilling admits to being "a huge WoW player" and a fan of Sony and military simulations. "We're not looking to knock off WoW or beat the MMO space, but flush out this unbelievable intellectual property we have and converge the audiences of Salvatore and Todd over the next four or five years, so hundreds of millions of people will come across our Web site," said Schilling. "We'll succeed or fail on our own merit." The London-based research firm Screen Digest said the MMO market reached $1 billion in subscription revenue for Europe and the Americas for the first time in 2006 ($576 million in North American and $299 million in Europe.) Subscription revenue accounted for 87 percent of that market, but Screen Digest noted the growing importance that in-game advertising and virtual sale items (such as weapons) have made. Screen Digest forecasts that by 2011, more than 10 million subscription accounts will generate $1.5 billion in consumer spending. It's a big market, but 38 Studios faces plenty of challenges from established players as well as new ones coming out of left field, even if they lack a baseball pedigree. "Assuming they have the resources and experience, two years is still a long time," Gartner analyst Mike McGuire told InternetNews.com. "It's a gamble they create something that's compelling enough to get consumers to stop doing less of something they're already investing time in. I don't buy into this idea that we'll all just continue to invest more and more time with online media." On the other hand, McGuire said 38 Studios has the right idea in focusing on community. "Whether it's games, news, music or new business opportunities, everything has to be geared to communities, not individuals. That's the old model -- you target, say, 15- to 34-year-old males. No -- now you go for online communities to get at individuals." Another challenge for 38 Studios (which was named for Schilling's jersey number) might be location. Suburban Maynard, Mass., is hardly a gaming mecca, and Schilling said he was told he'd lose talent basing the company in Boston. "But my view was if being in Boston means we lose you, then it wasn't meant to be, they don't buy into the vision of what we're doing," he said. Schilling said the people he's brought in to the self-funded 38 Studios thus far have a common vision, and he's getting up to speed leading the enterprise. "Before last year, I thought 'burn rate' was my fastball velocity," Schilling joked to the room full of venture capitalists. "When I'm on the mound sixty feet away, I'm going to beat you," he added. "In this I'm not the smartest guy in the room and I'm okay with that, but I want to have a clue when they're talking about how they want to work the pipeline or the poly count for a game." Now that Schilling can talk more of the talk, he's on the hunt for investors. "We've done a lot of work already, now we're looking for someone who gets us," he said. "We're going to make someone other than us filthy rich." Schilling in legendary in baseball circles for the preparation he does before games and plans to bring that same dogged attitude to the games business. "You can save yourself hundreds of millions of dollars now that you might not realize you didn't have to spend until it's too late," he said. As a manager, Schilling added that he takes a personal interest in all his employees. "You'll never work for someone who cares more about you and your family." But his employees shouldn't get too comfortable -- the other side of Schilling's approach is an insistence you adhere to two rules: "Show up on time and bust your ass."